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Sectors: Health, Research

Beneficiaries: Federations Unions, Non-profit organisations, Research centres, Schools, SMEs, Training centres, Universities

Regions: European Union, Worldwide

Category: Call for proposals


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Additional info regions:

Worldwide : Associated countries


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Responsible: European Comission


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This call for proposals aims to support the conduct of research related to the future of medicine in areas of public health interest where societal, public health and biomedical industry competitiveness goals are aligned and the pooling of resources and greater collaboration between the public and private sectors is required.

Priorities and funded actions:

– Topic 1:Development of Quantitative System Toxicology (QST) approaches to improve the understanding of the safety of new medicines
– Topic 2:Establishing impact of Human respiratory syncytial virus (RSV) infection, resultant disease and public health approach to reduce the consequences
– Topic 3:Real World Outcomes across the Alzheimer’s disease (AD) Spectrum (ROADS) to better care
– Topic 4:Development of an outcomes-focused data platform to empower policy makers and clinicians to optimize care for patients with hematologic malignancies (HM) 

Priorities and financed actions
Topic 1 :
– Develop an open, focused and sustainable knowledge database to build system toxicology models
– Provide a clearer understanding of the translational confidence from non-clinical species to human
– Support key risk assessment decisions using mechanistic and quantitative modelling
– Provide improved methods for visualizing and analyzing complex high content data to support drug safety assessment  
– Help inform regulatory decisions 

Topic 2 :
– Create a multi-disciplinary, multi-stakeholder community with an in-depth comprehension of the burden of RSV on healthcare systems and societies
– Assess synergies involved to study other pathogens depending on potential partner core capabilities and interest
– inventory of available initiatives, knowledge and past and present efforts to increase our understanding of RSV
– generate an analysis of the costs associated with RSV infections 
– provide for transparent reporting on data and analyses on RSV infection generated in the project
– improve linkage between public health perspectives on management of RSV and incentives for R&D investment
– leverage existing cohorts and epidemiology networks, or establish new ones, to explore biomarkers 

Topic 3 :
– Define a minimum set of measurable patient relevant real world outcomes
– Develop recommendations on appropriate AD-related cognitive, functional, and behavioural endpoints that can be used across various types of real-world research programs and data systems 
– Identify data sources and outline a data strategy
– Identify new methods and technologies for incorporation into clinical and social care practice 
– Provide recommendations of different approaches to model disease progression depending on data sources to enable better treatment selection and improved health care value for AD

Topic 4 :
– define standard sets of outcomes for Hematologic malignancies (HMs) that are relevant and meaningful to patients and clinicians in order to to provide an understanding of how to measure data on HMs
– Communicate and support the use of the defined standard outcomes data sets on selected HMs
– develop a data sharing platform that empowers clinicians and policy stakeholders to improve decision making and provide appropriate treatments to patients with HMs
– Propel key medical and policy initiatives through fact based decisions from much larger and diverse data sets that have been harmonized and queried by medical and non-medical experts
– Outline a plan to ensure sustainability of the platform beyond the lifetime of the proposed project
– Ensure the partnership collaborates with and builds on other IMI projects