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Sectors: Health, Research

Beneficiaries: Corporations, Research centres

Regions: European Union

Category: Call for proposals


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Responsible: European commission


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This call for proposals aims to develop a detailed understanding of the epidemiology and clinical impact of Clostridium Difficile infection.

Priorities and funded actions:

– Align and understand the unmet public health needs relating to CDI;
– Identify the direct and long-term burden on healthcare systems;
– Set up an EU research platform that will provide support for potential proof-of-concept studies of new prevention and treatment strategies.  

Work package 1: Epidemiology of Clostridium difficile
– CDI incidence in hospital, community and nursing home / long-term care facilities (LTCF);
– strain distribution;
– identification of high-risk groups for CDI, recurrences and negative outcomes;
– rate of recurrence, morbidity and mortality (including attributable mortality) for the general population and subgroups identified above;
– disease transmission model.
Work package 2: Disease detection and management (topics to address 🙂
– Heterogeneity in testing density and in following the existing guidance (including identification of missed diagnoses and empiric treatment approach practices);
– Current surveillance practices and ways to improve them;
– Current guidelines for disease detection, notification and management/control;
– Treatment pathway for patients with CDI infection and recurrences;
Work package 3: Build a research network and platform
– Creation of a multidisciplinary EU-based research platform. The platform will consist of researchers, medical and scientific societies, patients, R&D companies and venture capital (VC) firms interested and engaged in CDI. It will provide support for potential proof-of-concept studies through easy access to laboratory facilities, clinical trial sites, etc.
Work package 4: Coordination and project management
– Establishment of an effective governance and internal communication procedures to allow for the flow of information within the project as well.

Among financed actions
– Create and communicate a multifaceted understanding of CDI epidemiology across the European region.
– Provide insights into the differences in incidence, strain prevalence, reporting and testing practices, current control measures, diagnosis and treatment variations within and between countries.
– Quantify the burden of disease (including primary infections and recurrence) and outcomes related to the disease in acute hospital, nursing home/long-term care facility and community settings.